Fourth International Symposium on

Resistant Gram-Positive Infections

   
   

 

Abstracts from the Third International Symposium on Resistant Gram-Positive Infections in 2006 are listed below.

(Click on title to read abstract.)

   
   
   
   

CPLA #1:Clostridium difficile Antibody Titers Prior to and Following IVIG for Relapsing Colitis.

Authors: *Lawrence A. Cone,1,2 Michael S. Somero,1 Radhika Gade-Andavolu2.

Affiliations: 1Eisenhower Medical Center: 2 Genetic Research Institute of the Desert, Rancho Mirage, CA, USA 


CPLA #2: Screening for Nasal Colonization with Methicillin-Resistant Staphylococcus aureus (MRSA) on Admission to the Neonatal Intensive Care Unit (NICU). 

Authors: *Jeremias L Murillo,1  Pat Harmon,1 Wilfredo Cruz,1 Trini Chan,1 Morris Cohen,1 Madhavi Koraboina,2  Barry Kreiswirth,2

Affiliations: 1 Newark Beth Israel Medical Center, Newark, NJ;  2 Public Health Research Institute, Newark, NJ.


CPLA #3: In vitro Susceptibility of Streptococcus pneumoniae to Ceftobiprole and Comparative b-Lactams. 

Authors: Peter C. Appelbaum,1 *Todd A. Davies,2 Karen Bush,2 Lois M. Ednie,1 Tatiana Bogdanovich,1 Klaudia Kosowska1

Affiliations: 1 Hershey Medical Center, Hershey, PA; 2 Johnson & Johnson Pharm. Res. & Dev., Raritan, NJ.


CPLA #4: Multi-drug Resistant Type 19A Streptococcus pneumoniae Following Introduction of Conjugate Pneumococcal Vaccine. 

Authors: *Michael R. Jacobs, Caryn Good, Saralee Bajaksouzian, Anne Windau,

Affiliations:  Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH.


CPLA #5: Activity of Ceftobiprole against Methicillin Susceptible and Resistant Staphylococci. 

Authors: *Michael R. Jacobs,1 Karen Amsler,2 Saralee Bajaksouzian,1 Anne Windau,1 Lois M. Ednie,3 Tatiana Bogdanovich,3 Peter C. Appelbaum.3 

Affiliations:  1 Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH; 2 Johnson & Johnson Pharm. Res. & Dev., Raritan, NJ; 3 Hershey Medical Center, Hershey, PA.


CPLA #6: Successful Treatment of Chronic MRSA Sinusitis with Daptomycin.

Authors: George B Baxter,1 Gail T. Gerena,2 John A Vande Waa,1 William B. Norris, *Keith M. Ramsey.1,3

Affiliations:  1.University of South Alabama, Mobile, AL; 2.Danville Regional Medical Center, Danville, VA; 3.Brody School of Medicine at East Carolina University, Greenville, NC.


CPLA #7: Characterization of Mupirocin Resistance in MRSA from Saskatchewan.

Authors: *Christine G Siemens1, Ryan McDonald2, Paul Levett2, Greg Horsman2, Mohammad Khan3, Mandiangu Nsungu4, James Irvine5, Michael R. Mulvey1,6, and the Northern Antimicrobial Resistance Partnership

Affiliations: 1.University of Manitoba, Winnipeg, MB; 2.Provincial Laboratory, Saskatchewan Health, Regina, SK.; 3.Kelsey Trail Health Region, Melfort, SK.; 4.Northern Intertribal Health Authority, SK.; 5.Keewatin-Yatthe Regional Health Authority, SK; 6.National Microbiology Laboratory, Winnipeg, MB.


CPLA #8: Characterization of Panton-Valentine Leukocidin Negative CMRSA7 (USA400) Community-Associated Methicillin-Resistant Staphylococcus aureus

Authors: *Christine G Siemens1, George R Golding1, Michael R. Mulvey1,2, and the Canadian Nosocomial Infection Surveillance Program

Affiliations: 1.University of Manitoba, Winnipeg, MB, Can. 2.Public Health Agency of Canada, Winnipeg, MB, Can.


CPLA #9: Emergence of Four New Epidemic Strains of Methicillin-Resistant Staphylococcus aureus in Canada

Authors: *Jennifer L. Campbell1, David Spreitzer1, Christine Watt2, Andrew. E. Simor2, Marianna Ofner3, Denise Gravel3, Shirley Paton3, Allison McGeer4, Mark Loeb5, Elizabeth. Bbryce6, Ann Matlow7, Michael R. Mulvey1 and The Canadian Nosocomial Infection Surveillance Program.

Affiliations: 1National Microbiology Laboratory, Winnipeg, MB, 2Sunnybrook Health Sciences Centre, Toronto, ON, 3The Division of Nosocomial Infection and Occupational Infections, Ottawa, ON, 4Mount Sinai Hospital, Toronto, ON, 5McMaster University, Hamilton, ON, 6Vancouver General Hospital, Vancouver, BC, 7Hospital for Sick Children, Toronto, ON.


CPLA #10: Microbiological Activity of Ceftobiprole Against Enterococci. 

Authors: C.A. Arias, K. V. Singh, *B. E. Murray. 

Affiliations: Univ. of Texas Health Ctr., Houston, TX.


CPLA #11: Pharmacokinetic Modeling of Telavancin Penetration into Skin Blister Fluid.

Authors: *Shekman L. Wong,1 Jeng-Pyng Shaw,1 David P. Nicolau,2 Steven L. Barriere,1 Michael M. Kitt,1 Michael R. Goldberg.1

Affiliations: 1.Theravance, Inc., South San Francisco, CA, USA; 2.Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.


CPLA #12: Telavancin (TLV) Is More Bactericidal Than Vancomycin (VAN) against Both Extracellular and Intracellular (THP-1 Macrophages) Staphylococcus aureus with Different Resistance Phenotypes.

Authors: Maritza Barcia-Macay, Sandrine Lemaire, Marie-Paule Mingeot-Leclercq, *Paul M. Tulkens, Françoise Van Bambeke. .

Affiliations: Université Catholique de Louvain, Brussels, Belgium.


CPLA #13: Evidence for a Multivalent Interaction between Telavancin and Membrane-Bound Lipid II.

Authors: *Eefjan J. Breukink,1 Inge Visscher,1 Patrick P. A. Humphrey2, Bret M. Benton.2,1.

Affiliations: 1Utrecht University, Utrecht, The Netherlands; 2.Theravance, Inc., South San Francisco, CA, USA.


CPLA#14: Telavancin Is Efficacious in a Murine Model of Staphylococcal Pneumonia.

Authors: *Sharath S. Hegde, Noe Reyes, Robert Skinner.

Affiliations: Theravance, Inc., South San Francisco, CA, USA.


CPLA #15: Flow Cytometry Analysis of the Effects of Telavancin on Staphylococcus aureus Plasma Membrane Potential and Permeability.

Authors: *Marika Renelli, Christopher J. Linnevers, Patrick P. A. Humphrey, Mathai Mammen, Bret M. Benton.

Affiliations: Theravance, Inc., South San Francisco, CA, USA.


CPLA #16: Telavancin Demonstrates a Low Potential for In Vitro Selection of Resistance among Key Target Gram-Positive Species.

Authors: *Daniel F. Sahm,1 Bret M. Benton,2 Michael A. Cohen,1 Mark E. Jones,3 Kevin M. Krause,1 Clyde Thornsberry,1 Deborah C. Draghi.1

Affiliations: 1.Focus Bio-Inova, Inc., Herndon, VA, USA; 2.Theravance, Inc., South San Francisco, CA, USA; 3.Focus Bio-Inova, Inc., Plaisir, France.


CPLA #17: Effects of Human Serum on In Vitro Activity of Telavancin.

Authors: *Patrick F. Smith, Brian T. Tsuji, Pamela Kelchin, Olanrewaju O. Okusanya, Alan Forrest.

Affiliations: State University of New York at Buffalo, Buffalo, NY, USA.


CPLA #18: Compartmental Analysis of Telavancin Penetration into Epithelial Lining Fluid and Alveolar Macrophages.

Authors: *Shekman L. Wong,1.Jeng-Pyng Shaw,1.Mark H. Gotfried,2.Steven L. Barriere,1. Michael M. Kitt,1.Michael R. Goldberg.1

Affiliations: 1.Theravance, Inc., South San Francisco, CA, USA; 2.Pulmonary Associates, Phoenix, AZ, USA.


CPLA #19: Baseline Antistaphylococcal Profile of Telavancin; Results of the 2005 US Surveillance Initiative.

Authors: *Deborah C. Draghi,1 Bret M. Benton,2 Michael A. Cohen,1 Mark E. Jones,3 Kevin M. Krause,2 Clyde Thornsberry,1 Daniel F. Sahm.1

Affiliations: 1.Focus Bio-Inova, Inc., Herndon, VA, USA;2.Theravance, Inc., South San Francisco, CA, USA;3.Focus Bio-Inova, Inc., Plaisir, France.


CPLA #20: Exposure of Staphylococcus aureus Isolates to Daptomycin (Alone or with Vancomycin) Leads to a Diminished Macrophage Inflammatory Response (Compared with Vancomycin Alone). 

Authors: *B Keith English1,2, Erik M Maryniw1,2, Ajay J Talati1,2 and Elizabeth A Meals1,2.

Affiliations: 1Children's Foundation Research Center at Le Bonheur Children's Medical Center and 2University of Tennessee Health Science Center, Memphis, TN 38103.


CPLA #22: Killing of Streptococcus pneumoniae (SP) by Azithromycin (AZ), Clarithromycin (CL), Telithromycin (TL) and Gemifloxacin (GM) Using the Minimum Inhibitory (MI) and Mutant Prevention (MP) Drug Concentration (C). 

Authors: J. M. Blondeau¹, S.D. Borsos2.

Affiliations: 1.Department of Clinical Microbiology, Royal University Hospital, Department of Microbiology and Immunology, Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada.  2.Department of Clinical Microbiology, Royal University Hospital, Saskatoon, SK, Canada


CPLA #23: The Effect of Antibiotic Resistance in S. pneumoniae on Clinical Outcome of Respiratory Tract Infections Treated with Gemifloxacin.

Authors: Morrissey, I1, File Jr., TM2 and Mandell, LA3. 

Affiliations: 1GR Micro Ltd., London, UK., 2Summa Health System, Akron, OH, USA, 3 McMaster University, Hamilton, Canada,4


CPLA #24: Resistance in Streptococcus pneumoniae:  AUC/MIC Breakpoints Differ between  Gatifloxacin, Gemifloxacin, Levofloxacin, and Moxifloxacin 

Authors:  KL LaPlante1, MJ Rybak1,2  BT Tsuji1, GW Kaatz1,2,3

Affiliations: 1 Anti Infective Research Laboratory, Department of Pharmacy Practice, 2 School of Medicine, 3 Wayne State University & The John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan USA


CPLA #25: Fluoroquinolone Resistance and Its Association with Other Resistances in Streptococcus pneumoniae in the UK and Ireland

Authors: R. Reynolds, D. Felmingham, BSAC Working Party on Respiratory Resistance Surveillance

Affiliations: British Society for Antimicrobial Chemotherapy (BSAC), Birmingham, UK; GR Micro Ltd., London, UK.


CPLA #26: Determination of the Mutant Prevention Concentration (MPC) & Minimal Inhibitory Concentration (MIC) of Gemifloxacin (GM) against Penicillin Susceptible (PS) & Resistant (PR) Clinical Isolates of Streptococcus pneumoniae (SP).

Authors: J. M. Blondeau¹, S.D. Borsos2.

Affiliations: 1.Department of Clinical Microbiology, Royal University Hospital, Department of Microbiology and Immunology, Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada. 2.Department of Clinical Microbiology, Royal University Hospital, Saskatoon, SK, Canada


CPLA #27: Efficacy and Safety of Daptomycin (DAP) for the Treatment of Skin and Skin Structure Infections (SSSI).

Authors: *Jack Brown, Kenneth C. Lamp, Lawrence V. Friedrich.  

Affiliations:  Cubist Pharmaceuticals, Lexington, MA


CPLA #28: Effect of Thymidine on the Activity of Diaminopyrimidine Antibacterial Agents

Authors: Stephen Hawser, Muriel Bihr, Laurent Weiss, Khalid Islam and *Sergio Lociuro

Affiliations:  Arpida AG, Switzerland.


CPLA #29: Concentrations of Iclaprim in Plasma, Epithelial Lining Fluid (elf) Alveolar Macrophages (am) and Bronchial Mucosa (bm) Following a Single 1.6 Mg/kg Intravenous Infusion in Healthy Subjects.

Authors:*Paul Hadvary1,Jenny Andrews2, David Honeybourne 3, Janet Ashby2, Gail Jevons2, Adam Fraise2, Patricia Fry4, Richard Wise2;

Affiliations:1Arpida AG, Switzerland, 2City Hosp., Birmingham, United Kingdom, 3Heartlands Hosp., Birmingham, United Kingdom, 4Hammersmith Med. Res. Limited, London, United Kingdom


CPLA #30: In vitro Plasma Fibrin Clot Models Versus in vivo Models of Experimental Endocarditis: Case Study for Diaminopyrimidine Antibiotics Iclaprim and Trimethoprim/Sulfamethoxazole

Authors:*Stephen Hawser1, Jose Entenza2, Marlyse Giddey2, Jacques Vouillamoz2, Phillippe Moreillon2 and Khalid Islam1

Affiliations:1Arpida AG, Switzerland and 2University of Lausanne, Switzerland


CPLA #31:  Efficacy and Safety of Intravenous Iclaprim in Complicated Skin and Skin Structure Infections: Results of a Phase 2 Study

Authors: Dainis Krievens 1, Anton Leighton2, Roger Brandt 2, *Paul Hadvary 2, Stephen Hawser2, Dieter Gillessen 2 and Khalid Islam2; 1Stradini

Affiliations: Clinical Univ. Hosp., Riga, Latvia, 2Arpida AG, Switzerland.


CPLA #32:  In vitro Spectrum of Activity of Iclaprim Against Various Gram-positive and Gram-negative Pathogens

Authors: *Stephen Hawser, Sergio Lociuro, Khalid Islam

Affiliations: Arpida AG, Switzerland


CPLA #33:  Pharmacokinetics of Single and Multiple Doses of Iclaprim Given by Intravenous Infusion in Healthy Volunteers

Authors: Roger Brandt1, Stuart Irons2, Alan McBurney2, Virginia Norris2, Steve Warrington3 Torben Thomsen4, *Paul Hadvary1 and Khalid Islam1

Affiliations:1 Arpida AG, Switzerland, 2Huntingdon Life Sciences Ltd, England, 3Hammersmith Medicines Research, England, 4Pharma PlanNet Contract Research GmbH, Germany, 


CPLA #34: In vitro Activity of Iclaprim against Staphylococcus aureus, Group A and Group B Streptococci

Authors:*Stephen Hawser, Sergio Lociuro, Khalid Islam

Affiliations: Arpida AG, Switzerland

   
   
   
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