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CPLA
#1:Clostridium difficile Antibody Titers Prior to and Following IVIG for
Relapsing Colitis.
Authors: *Lawrence A. Cone,1,2 Michael S. Somero,1 Radhika Gade-Andavolu2.
Affiliations: 1Eisenhower Medical Center: 2 Genetic Research
Institute of the Desert, Rancho Mirage, CA, USA
CPLA #2: Screening for
Nasal Colonization with Methicillin-Resistant Staphylococcus aureus
(MRSA) on Admission to the Neonatal Intensive Care Unit (NICU).
Authors: *Jeremias L Murillo,1 Pat
Harmon,1 Wilfredo Cruz,1 Trini Chan,1 Morris Cohen,1 Madhavi Koraboina,2 Barry
Kreiswirth,2
Affiliations: 1 Newark Beth Israel Medical Center, Newark, NJ;
2 Public Health Research Institute, Newark, NJ.
CPLA #3: In vitro Susceptibility of Streptococcus pneumoniae to
Ceftobiprole and Comparative b-Lactams.
Authors: Peter C. Appelbaum,1 *Todd A. Davies,2 Karen
Bush,2 Lois M. Ednie,1 Tatiana Bogdanovich,1 Klaudia Kosowska1
Affiliations: 1 Hershey
Medical Center, Hershey, PA; 2 Johnson & Johnson Pharm. Res. & Dev.,
Raritan, NJ.
CPLA #4: Multi-drug Resistant Type 19A Streptococcus pneumoniae Following
Introduction of Conjugate Pneumococcal Vaccine.
Authors: *Michael R. Jacobs, Caryn Good, Saralee
Bajaksouzian, Anne Windau,
Affiliations: Case
Western Reserve University and University Hospitals of Cleveland, Cleveland, OH.
CPLA #5: Activity of Ceftobiprole against Methicillin
Susceptible and Resistant Staphylococci.
Authors: *Michael R. Jacobs,1 Karen Amsler,2 Saralee
Bajaksouzian,1 Anne Windau,1 Lois M. Ednie,3 Tatiana Bogdanovich,3 Peter C.
Appelbaum.3
Affiliations: 1
Case
Western Reserve University and University Hospitals of Cleveland, Cleveland, OH;
2 Johnson & Johnson Pharm. Res. & Dev., Raritan, NJ; 3 Hershey Medical
Center, Hershey, PA.
CPLA
#6: Successful Treatment of Chronic MRSA Sinusitis with Daptomycin.
Authors: George
B Baxter,1
Gail T. Gerena,2 John A Vande Waa,1 William
B. Norris, *Keith M. Ramsey.1,3
Affiliations: 1.University
of South Alabama, Mobile, AL; 2.Danville Regional Medical Center, Danville, VA;
3.Brody School of Medicine at East Carolina University, Greenville, NC.
CPLA
#7: Characterization of Mupirocin Resistance in MRSA from Saskatchewan.
Authors: *Christine
G Siemens1, Ryan McDonald2, Paul Levett2, Greg Horsman2, Mohammad Khan3, Mandiangu Nsungu4, James Irvine5, Michael R. Mulvey1,6, and the Northern
Antimicrobial Resistance Partnership
Affiliations:
1.University of Manitoba, Winnipeg, MB; 2.Provincial Laboratory, Saskatchewan
Health, Regina, SK.; 3.Kelsey Trail Health Region, Melfort, SK.;
4.Northern Intertribal Health Authority, SK.; 5.Keewatin-Yatthe Regional Health
Authority, SK;
6.National Microbiology Laboratory, Winnipeg, MB.
CPLA #8: Characterization
of Panton-Valentine Leukocidin Negative CMRSA7 (USA400) Community-Associated
Methicillin-Resistant Staphylococcus aureus
Authors: *Christine G Siemens1, George R Golding1, Michael R.
Mulvey1,2, and the Canadian Nosocomial Infection Surveillance Program
Affiliations:
1.University of Manitoba, Winnipeg, MB, Can. 2.Public Health Agency of Canada,
Winnipeg, MB, Can.
CPLA #9: Emergence of Four New
Epidemic Strains of Methicillin-Resistant Staphylococcus aureus in Canada
Authors: *Jennifer L. Campbell1, David Spreitzer1,
Christine Watt2, Andrew. E. Simor2, Marianna Ofner3, Denise Gravel3, Shirley
Paton3, Allison McGeer4, Mark Loeb5, Elizabeth. Bbryce6, Ann Matlow7, Michael R.
Mulvey1 and The Canadian Nosocomial Infection Surveillance Program.
Affiliations: 1National
Microbiology Laboratory, Winnipeg, MB, 2Sunnybrook Health Sciences Centre,
Toronto, ON, 3The Division of Nosocomial Infection and Occupational Infections,
Ottawa, ON, 4Mount Sinai Hospital, Toronto, ON, 5McMaster University, Hamilton,
ON, 6Vancouver General Hospital, Vancouver, BC, 7Hospital for Sick Children,
Toronto, ON.
CPLA #10: Microbiological Activity of Ceftobiprole Against Enterococci.
Authors: C.A. Arias, K. V. Singh, *B. E. Murray.
Affiliations: Univ. of Texas Health Ctr., Houston, TX.
CPLA #11: Pharmacokinetic
Modeling of Telavancin Penetration into Skin Blister
Fluid.
Authors: *Shekman L. Wong,1 Jeng-Pyng Shaw,1 David P. Nicolau,2 Steven L. Barriere,1
Michael M. Kitt,1 Michael R.
Goldberg.1
Affiliations: 1.Theravance,
Inc., South San Francisco, CA, USA; 2.Center for Anti-Infective Research and
Development, Hartford Hospital, Hartford, CT, USA.
CPLA #12: Telavancin (TLV) Is More Bactericidal Than
Vancomycin (VAN) against Both Extracellular and Intracellular (THP-1
Macrophages) Staphylococcus aureus
with Different Resistance Phenotypes.
Authors: Maritza Barcia-Macay, Sandrine Lemaire,
Marie-Paule Mingeot-Leclercq, *Paul M. Tulkens, Françoise Van Bambeke. .
Affiliations: Université Catholique de Louvain, Brussels,
Belgium.
CPLA
#13: Evidence
for a Multivalent Interaction between Telavancin and Membrane-Bound Lipid II.
Authors:
*Eefjan
J. Breukink,1 Inge Visscher,1 Patrick P. A. Humphrey2,
Bret M. Benton.2,1.
Affiliations:
1Utrecht
University, Utrecht, The Netherlands; 2.Theravance, Inc., South San Francisco,
CA, USA.
CPLA#14:
Telavancin Is Efficacious in a Murine
Model of Staphylococcal Pneumonia.
Authors:
*Sharath S. Hegde, Noe Reyes, Robert Skinner.
Affiliations:
Theravance, Inc., South San Francisco, CA, USA.
CPLA
#15: Flow Cytometry Analysis of the
Effects of Telavancin on Staphylococcus
aureus Plasma Membrane Potential and
Permeability.
Authors: *Marika Renelli, Christopher J. Linnevers, Patrick
P. A. Humphrey, Mathai Mammen, Bret M. Benton.
Affiliations: Theravance, Inc., South San Francisco, CA, USA.
CPLA
#16: Telavancin
Demonstrates a Low Potential for In Vitro Selection of Resistance among Key
Target Gram-Positive Species.
Authors: *Daniel F. Sahm,1 Bret
M. Benton,2 Michael A. Cohen,1 Mark E. Jones,3 Kevin M. Krause,1 Clyde
Thornsberry,1 Deborah C. Draghi.1
Affiliations: 1.Focus Bio-Inova, Inc.,
Herndon, VA, USA; 2.Theravance, Inc., South San Francisco, CA, USA;
3.Focus Bio-Inova,
Inc., Plaisir, France.
CPLA
#17: Effects
of Human Serum on In Vitro Activity of Telavancin.
Authors: *Patrick
F. Smith, Brian T. Tsuji, Pamela Kelchin, Olanrewaju
O. Okusanya, Alan Forrest.
Affiliations:
State University of New York at Buffalo, Buffalo, NY, USA.
CPLA
#18: Compartmental Analysis of Telavancin Penetration into Epithelial Lining
Fluid and Alveolar Macrophages.
Authors: *Shekman L. Wong,1.Jeng-Pyng Shaw,1.Mark
H. Gotfried,2.Steven
L. Barriere,1. Michael M. Kitt,1.Michael
R. Goldberg.1
Affiliations: 1.Theravance, Inc., South
San Francisco, CA, USA; 2.Pulmonary Associates, Phoenix, AZ, USA.
CPLA #19: Baseline Antistaphylococcal Profile of
Telavancin; Results of the 2005 US Surveillance Initiative.
Authors: *Deborah
C. Draghi,1 Bret M. Benton,2 Michael
A. Cohen,1 Mark E. Jones,3 Kevin M. Krause,2 Clyde Thornsberry,1 Daniel F.
Sahm.1
Affiliations: 1.Focus Bio-Inova, Inc.,
Herndon, VA, USA;2.Theravance, Inc., South San Francisco, CA, USA;3.Focus Bio-Inova,
Inc., Plaisir, France.
CPLA #20: Exposure of Staphylococcus
aureus Isolates to Daptomycin (Alone or with Vancomycin) Leads to a
Diminished Macrophage Inflammatory Response (Compared with Vancomycin Alone).
Authors: *B
Keith English1,2, Erik M Maryniw1,2, Ajay J Talati1,2 and Elizabeth A Meals1,2.
Affiliations: 1Children's Foundation Research Center at Le Bonheur Children's Medical
Center and 2University of Tennessee Health Science Center, Memphis, TN 38103.
CPLA #22: Killing of Streptococcus
pneumoniae (SP) by Azithromycin (AZ), Clarithromycin (CL), Telithromycin
(TL) and Gemifloxacin (GM) Using the Minimum Inhibitory (MI) and Mutant
Prevention (MP) Drug Concentration (C).
Authors: J. M. Blondeau¹, S.D.
Borsos2.
Affiliations:
1.Department
of Clinical Microbiology, Royal University Hospital, Department of Microbiology
and Immunology, Department of Pathology, University of Saskatchewan, Saskatoon,
SK, Canada. 2.Department of Clinical
Microbiology, Royal University Hospital, Saskatoon, SK, Canada
CPLA #23: The Effect of Antibiotic Resistance in S. pneumoniae on Clinical
Outcome of Respiratory Tract Infections Treated with Gemifloxacin.
Authors:
Morrissey, I1, File Jr., TM2 and Mandell, LA3.
Affiliations:
1GR
Micro Ltd., London, UK., 2Summa Health System, Akron, OH, USA, 3 McMaster
University, Hamilton, Canada,4
CPLA
#24: Resistance in Streptococcus pneumoniae: AUC/MIC
Breakpoints Differ between Gatifloxacin,
Gemifloxacin, Levofloxacin, and Moxifloxacin
Authors: KL LaPlante1, MJ Rybak1,2
BT Tsuji1, GW Kaatz1,2,3
Affiliations:
1 Anti Infective Research Laboratory, Department of
Pharmacy Practice,
2 School of Medicine, 3 Wayne State University & The
John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan USA
CPLA
#25: Fluoroquinolone Resistance and Its Association with Other Resistances in Streptococcus pneumoniae in the UK and Ireland
Authors: R. Reynolds, D.
Felmingham, BSAC Working Party on Respiratory Resistance Surveillance
Affiliations: British
Society for Antimicrobial Chemotherapy (BSAC), Birmingham, UK; GR Micro Ltd.,
London, UK.
CPLA
#26: Determination of the Mutant Prevention Concentration (MPC) & Minimal
Inhibitory Concentration (MIC) of Gemifloxacin (GM) against Penicillin
Susceptible (PS) & Resistant (PR) Clinical Isolates of Streptococcus
pneumoniae (SP).
Authors: J. M. Blondeau¹, S.D. Borsos2.
Affiliations: 1.Department of Clinical
Microbiology, Royal University Hospital, Department of Microbiology and
Immunology, Department of Pathology, University of Saskatchewan, Saskatoon, SK,
Canada. 2.Department of Clinical Microbiology, Royal University Hospital,
Saskatoon, SK, Canada
CPLA
#27: Efficacy and Safety of Daptomycin (DAP) for the Treatment of Skin and Skin
Structure Infections (SSSI).
Authors: *Jack Brown,
Kenneth C. Lamp, Lawrence V. Friedrich.
Affiliations: Cubist
Pharmaceuticals, Lexington, MA
CPLA
#28:
Effect of Thymidine on the Activity of
Diaminopyrimidine Antibacterial Agents
Authors: Stephen Hawser, Muriel
Bihr, Laurent Weiss, Khalid Islam and *Sergio Lociuro
Affiliations: Arpida AG, Switzerland.
CPLA
#29:
Concentrations of Iclaprim in Plasma, Epithelial Lining Fluid (elf)
Alveolar Macrophages (am) and Bronchial Mucosa (bm) Following a Single 1.6 Mg/kg
Intravenous Infusion in Healthy Subjects.
Authors:*Paul
Hadvary1,Jenny Andrews2, David Honeybourne 3, Janet Ashby2,
Gail Jevons2, Adam Fraise2, Patricia Fry4,
Richard Wise2;
Affiliations:1Arpida
AG, Switzerland, 2City Hosp., Birmingham, United Kingdom, 3Heartlands
Hosp., Birmingham, United Kingdom, 4Hammersmith Med. Res. Limited,
London, United Kingdom
CPLA #30: In
vitro
Plasma Fibrin Clot Models Versus in vivo
Models of Experimental Endocarditis: Case Study for Diaminopyrimidine
Antibiotics Iclaprim and Trimethoprim/Sulfamethoxazole
Authors:*Stephen
Hawser1, Jose Entenza2, Marlyse Giddey2,
Jacques Vouillamoz2, Phillippe Moreillon2 and Khalid Islam1
Affiliations:1Arpida AG, Switzerland and 2University
of Lausanne, Switzerland
CPLA #31: Efficacy and Safety of Intravenous Iclaprim in Complicated Skin and Skin
Structure Infections: Results of a Phase 2 Study
Authors: Dainis Krievens 1, Anton
Leighton2, Roger Brandt 2, *Paul Hadvary 2,
Stephen Hawser2, Dieter Gillessen 2 and Khalid Islam2;
1Stradini
Affiliations: Clinical Univ. Hosp., Riga, Latvia, 2Arpida
AG, Switzerland.
CPLA #32:
In
vitro
Spectrum of Activity of Iclaprim Against Various Gram-positive and Gram-negative
Pathogens
Authors:
*Stephen Hawser, Sergio Lociuro, Khalid Islam
Affiliations: Arpida AG,
Switzerland
CPLA #33: Pharmacokinetics of Single and Multiple Doses
of Iclaprim Given by Intravenous Infusion in Healthy Volunteers
Authors:
Roger Brandt1, Stuart Irons2, Alan McBurney2,
Virginia Norris2, Steve Warrington3 Torben Thomsen4,
*Paul Hadvary1 and Khalid Islam1
Affiliations:1
Arpida AG, Switzerland, 2Huntingdon Life
Sciences Ltd, England, 3Hammersmith Medicines Research, England, 4Pharma
PlanNet Contract Research GmbH, Germany,
CPLA #34: In vitro Activity of Iclaprim against Staphylococcus
aureus, Group A and Group B Streptococci
Authors:*Stephen
Hawser, Sergio Lociuro, Khalid Islam
Affiliations: Arpida
AG, Switzerland
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